Roger Unger

Too much, too little, at the wrong time: Zucara’s ZT-01 and the glucagon problem in type 1 diabetes

Zucara’s ZT-01: what could taking the brake off glucagon do?

23/09/2026 admin 0

ZT-01 aims to restore glucagon counterregulation during hypoglycaemia. But type 1 diabetes already produces glucagon at the wrong time — and Zucara’s own human data show SSTR2 blockade raises glucagon, glucose and insulin requirements during euglycaemia. What will the trials tell us about its longer term effects?

GLP1-RAs in Type 1 Diabetes: more than meets the eye?

08/10/2024 admin 11

Some people will be aware, and some not, that there is a reasonable minority of people with Type 1 Diabetes using GLP-1 Receptor Agonists (GLP1-RAs) […]

Glucagon me… n=1 experiments with microbolusing Glucagon part 1: setting a baseline

04/04/2023 admin 0

Everyone with type 1 is taught that the big orange plastic box that we’re supposed to keep in the fridge is for emergencies only and […]