Too much, too little, at the wrong time: Zucara’s ZT-01 and the glucagon problem in type 1 diabetes

Zucara’s ZT-01: what could taking the brake off glucagon do?

23/09/2026 admin 0

ZT-01 aims to restore glucagon counterregulation during hypoglycaemia. But type 1 diabetes already produces glucagon at the wrong time — and Zucara’s own human data show SSTR2 blockade raises glucagon, glucose and insulin requirements during euglycaemia. What will the trials tell us about its longer term effects?

Bolt AI into your loop and you might just have become a medical device manufacturer

28/08/2026 admin 0

Embedded AI is starting to appear in open source AID systems, offered as copy and paste, bring your own key, or a service the project runs. A year of measuring these models says the clinical risk is much the same in all three. The regulatory position is not, and the intuition about which is safest runs backwards.

The world’s first digital endocrinologist, and why you should keep your money.

The Libre Duo. A platform prototype to move care from the hospital to the home?

01/06/2026 admin 0

Abbott has put glucose and ketones on the same wearable, and the launch coverage is all about DKA. Worth having if you’re on a pump, which is fine as far as it goes, but it misses the bit that makes this interesting. Because if you look at what Abbott has actually built across its other divisions, and what they’ve patented alongside it, the Libre Duo doesn’t really look like a ketone sensor. It looks like the platform prototype and the first visible piece of an infrastructure designed to move chronic disease care out of outpatients and into the home. And the policy environment for that shift has just been locked in on both sides of the Atlantic for the next five years.