Did a change of glucagon derail the Inreda artificial pancreas trial?
Inreda’s recent year long study on their dual hormone AID system didn’t produce the results anyone wanted. Here we dig into that further.
glucagon
Zucara’s ZT-01: what could taking the brake off glucagon do?
ZT-01 aims to restore glucagon counterregulation during hypoglycaemia. But type 1 diabetes already produces glucagon at the wrong time — and Zucara’s own human data show SSTR2 blockade raises glucagon, glucose and insulin requirements during euglycaemia. What will the trials tell us about its longer term effects?
Glucagon me… n=1 experiments with microbolusing glucagon part 2: quantifying use
Are two hormones and an algorithm enough? Or is diabetes far more complex than that?
Glucagon me… n=1 experiments with microbolusing Glucagon part 1: setting a baseline
Everyone with type 1 is taught that the big orange plastic box that we’re supposed to keep in the fridge is for emergencies only and […]
Targeting insulin at the liver where it should be – Hepatocyte-Delivered Vesicle for Insulin
Whilst we are on the subject of novel diabetes treatments, I recently came across Hepatocyte Directed Vesicle Insulin from Diasome, and this one is a […]
Why isn’t Glucagon suppression part of Diabetes treatment?
Following discussions on the diabetes.co.uk forum recently, I decided that it was worth re-addressing the issue of Glucagon in the Type 1 Metabolic cycle. But […]
Why do Eggs cause high blood glucose in the absence of carbs? Here’syour answer…
Eggs, for many T1s, require almost as much insulin as carbohydrate. Yet eggs contain no noticeable carbs. What they do have is loads of protein […]
Diabetes Clinic Appointments – Harrumph…
Why Harrumph?. Sometimes they feel like an inordinate waste of time. Take mine today as an example. It was what I’d describe as frustrating and […]
Multi-Factor treatment of Type 1 Diabetes – how far off it are we?
Since getting my hands on my Freestyle Libre, I’ve been able to gain a whole new insight into how my diabetes works, and how my […]